LymphedemaV1, Main, Exploration, bibRecord, 002799

Mutation of Threonine 34 in Mouse Podoplanin-Fc Reduces CLEC-2 Binding and Toxicity in Vivo While Retaining Anti-lymphangiogenic Activity*

Identifieur interne : 002799 ( Main/Exploration ); précédent : 002798; suivant : 002800

Mutation of Threonine 34 in Mouse Podoplanin-Fc Reduces CLEC-2 Binding and Toxicity in Vivo While Retaining Anti-lymphangiogenic Activity*

Auteurs : Roberta Bianchi ; Eliane Fischer ; Don Yuen ; Ellen Ernst ; Alexandra M. Ochsenbein ; Lu Chen ; Vivianne I. Otto ; Michael Detmar

Source :

The Journal of Biological Chemistry [ 0021-9258 ] ; 2014.

RBID : PMC:4110307

Abstract

Background: Podoplanin-Fc inhibits lymphangiogenesis, but also causes a bleeding disorder by binding to CLEC-2 expressed on platelets.

Results: Mutation of threonine 34 in mouse Pdpn-Fc reduces 30-fold the binding to CLEC-2 and does not hamper its anti-lymphangiogenic activity.

Conclusion: PdpnT34A-Fc is an active lymphangiogenesis inhibitor with a better tolerability.

Significance: Mutagenesis of Pdpn-Fc is a valid approach to improve this tool for anti-lymphangiogenic therapy.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110307

DOI: 10.1074/jbc.M114.550525
PubMed: 24907275
PubMed Central: 4110307

Affiliations:

Le document en format XML

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 While Retaining Anti-lymphangiogenic Activity<xref ref-type="fn" rid="FN1">*</xref>
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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
 Podoplanin-Fc inhibits lymphangiogenesis, but also causes a bleeding disorder by binding to CLEC-2 expressed on platelets.</p>
<p><bold>Results:</bold>
 Mutation of threonine 34 in mouse Pdpn-Fc reduces 30-fold the binding to CLEC-2 and does not hamper its anti-lymphangiogenic activity.</p>
<p><bold>Conclusion:</bold>
 PdpnT34A-Fc is an active lymphangiogenesis inhibitor with a better tolerability.</p>
<p><bold>Significance:</bold>
 Mutagenesis of Pdpn-Fc is a valid approach to improve this tool for anti-lymphangiogenic therapy.</p>
</div>
</front>
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<name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name>
<name sortKey="Ernst, Ellen" sort="Ernst, Ellen" uniqKey="Ernst E" first="Ellen" last="Ernst">Ellen Ernst</name>
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<name sortKey="Yuen, Don" sort="Yuen, Don" uniqKey="Yuen D" first="Don" last="Yuen">Don Yuen</name>
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Mutation of Threonine 34 in Mouse Podoplanin-Fc Reduces CLEC-2 Binding and Toxicity in Vivo While Retaining Anti-lymphangiogenic Activity*

Mutation of Threonine 34 in Mouse Podoplanin-Fc Reduces CLEC-2 Binding and Toxicity in Vivo While Retaining Anti-lymphangiogenic Activity*

Source :

Abstract

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